Interaction of Synuclein and inflammation in Dopaminergic Neurodegeneration PRINCIPAL INVESTIGATOR:

TITLE: Interaction of Synuclein and Inflammation in Dopaminergic Neurodegeneration

Fk506&reduces&neuroinflammation&and&dopaminergic& Neurodegeneration&in&an&α8synuclein8based&rat&model&for& Parkinson's&disease.% Fk506 Reduces Neuroinflammation and Dopaminergic Neurodegeneration in an - Synuclein-based Rat Model for Parkinson's Disease Authors

Alpha-synuclein (-synuclein) is considered a key player in Parkinson's disease (PD), but the exact relationship between-synuclein aggregation and dopaminergic (DA) neurodegeneration remains unresolved. There is increasing evidence that neuroinflammatory processes are closely linked to DA cell death, but whether the inflammatory process is causally involved in PD or rather reflects secondary con...

Parkinson's disease: Microglial/macrophage-induced immunoexcitotoxicity as a central mechanism of neurodegeneration

Parkinson's disease is one of the several neurodegenerative disorders that affects aging individuals, with approximately 1% of those over the age of 60 years developing the disorder in their lifetime. The disease has the characteristics of a progressive disorder in most people, with a common pattern of pathological change occurring in the nervous system that extends beyond the classical striata...

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons.

OBJECTIVE Whereas the contribution of α-synuclein to neurodegeneration in Parkinson disease is well accepted, the putative impact of its close homologue, β-synuclein, is enigmatic. β-Synuclein is widely expressed throughout the central nervous system, as is α-synuclein, but the physiological functions of both proteins remain unknown. Recent findings have supported the view that β-synuclein can ...

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation.

Subpopulations of dopaminergic (DA) neurons within the substantia nigra pars compacta (SNpc) display a differential vulnerability to loss in Parkinson's disease (PD); however, it is not clear why these subsets are preferentially selected in PD-associated neurodegeneration. In rodent SNpc, DA neurons can be divided into two subpopulations based on the expression of aldehyde dehydrogenase 1 (ALDH...